Live immunisation against Theileria parva: containing or spreading the disease?
نویسندگان
چکیده
منابع مشابه
Optimisation and Rationalisation of Cattle Immunisation against Theileria parva in Eastern Zambia
The most serious constraint of cattle rearing in Eastern Zambia has been East Coast Fever (ECF), and acute and often lethal tick-borne disease caused by the protozoan Theileria parva. A method of immunisation known as “infection and treatment” was developed in the seventies and has, so far, been the only efficient and available immunoprophylactic control method. It is done by inoculating cattle...
متن کاملApproaches to vaccination against Theileria parva and Theileria annulata
Despite having different cell tropism, the pathogenesis and immunobiology of the diseases caused by Theileria parva and Theileria annulata are remarkably similar. Live vaccines have been available for both parasites for over 40 years, but although they provide strong protection, practical disadvantages have limited their widespread application. Efforts to develop alternative vaccines using defi...
متن کاملLimited genetic and antigenic diversity within parasite isolates used in a live vaccine against Theileria parva
An infection and treatment protocol is used to vaccinate cattle against Theileria parva infection. Due to incomplete cross-protection between different parasite isolates, a mixture of three isolates, termed the Muguga cocktail, is used for vaccination. While vaccination of cattle in some regions provides high levels of protection, some animals are not protected against challenge with buffalo-de...
متن کاملCharacterization of the Theileria parva sporozoite proteome
East Coast fever is a lymphoproliferative disease caused by the tick-borne protozoan parasite Theileria parva. The sporozoite stage of this parasite, harboured and released from the salivary glands of the tick Rhipicephalus appendiculatus during feeding, invades and establishes infection in bovine lymphocytes. Blocking this initial stage of invasion presents a promising vaccine strategy for con...
متن کاملInfluence of host immunity on parasite diversity in Theileria parva.
We examined the influence of host immunity on the genotypic diversity of the intracellular transforming cattle parasite Theileria parva. By tracking the emergence of discrete parasite genotypes in an animal challenged with a bulk stabilate following immunization with its major component clone, we observed a profound modulation of genotypic frequencies in the breakthrough schizont population. In...
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ژورنال
عنوان ژورنال: Trends in Parasitology
سال: 2007
ISSN: 1471-4922
DOI: 10.1016/j.pt.2007.09.002